Matthew C. Zimmerman, PhD

Hypertension (high blood pressure) is a cardiovascular disease associated with increased activity of brain cells called neurons. Elevated levels of molecules called reactive oxygen species (ROS) in neurons have been shown to be involved in the development and progression of hypertension. Matthew C. Zimmerman, PhD, and his laboratory investigate the precise location of ROS generation in neurons and how these ROS control neuronal activation, particularly how ROS act as signaling intermediates to regulate redox-sensitive proteins that ultimately control neuronal ion channel activity. In addition, he investigates how antioxidant enzymes work to decrease neuronal activation and lower blood pressure. In examining these unknowns, the laboratory strives to advance opportunities to develop new therapeutics that may need to be targeted to specific neuronal cell populations and/or subcellular compartments for the improved treatment of hypertension.

Courtesy of the University of Nebraska Medical Center, Office of Strategic Communications